Activated by the antibiotic rifampicin and several plant metabolites, including hyperforin, guggulipid, colupulone, and isoflavones. Reaction to distinct ligands is species-particular. Activated by Normally taking place steroids, like pregnenolone and progesterone. Binds to the response component in the promoters on the CYP3A4 and ABCB1/MDR1 genesA